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KMID : 0043320200430121215
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Archives of Pharmacal Research
2020 Volume.43 No. 12 p.1215 ~ p.1229
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Recent progresses in marine microbial-derived antiviral natural products
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Teng Yun-Fei
Xu Li
Wei Mei-Yan
Wang Chang-Yun
Gu Yu-Cheng
Shao Chang-Lun
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Abstract
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Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have been isolated from marine microorganisms, of which 35 exhibit anti-H1N1 activity. This review surveys systematically marine microbial-derived natural products with antiviral activity and illustrates the impact of these compounds on antiviral drug discovery research.
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KEYWORD
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Antiviral activity, Marine microorganism, Marine natural products, Structure?activity relationships
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